Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | overexpression of katanin results in 12% loss of microtubule mass, low degradation of microtubule array in katanin-overexpressing neurons | Rattus norvegicus | |
additional information | overexpression of spastin result in 30% loss of microtubule mass, increase in axonal branching in spastin-overexpressing neurons, degrade of microtubule array in spastin-overexpressing neurons | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | slowed development, shorter axons and fewer axonal branches in spastin-depleted neurons | Rattus norvegicus | |
protein tau | affords protection of microtubules in katanin-overexpressing neurons | Rattus norvegicus | |
Tau | affords some protection of microtubules in spastin-overexpressing neurons | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | - |
Rattus norvegicus | - |
hippocampal cell line | - |
Rattus norvegicus | - |
RFL-6 cell | - |
Rattus norvegicus | - |
Synonyms | Comment | Organism |
---|---|---|
kananin | - |
Rattus norvegicus |
P60-kananin | - |
Rattus norvegicus |
spastin | isoform M85 | Rattus norvegicus |